{"id":775,"date":"2026-01-27T12:33:39","date_gmt":"2026-01-27T12:33:39","guid":{"rendered":"https:\/\/portfolio.zenkoders.com\/ai-powered\/?p=775"},"modified":"2026-04-08T22:46:49","modified_gmt":"2026-04-08T22:46:49","slug":"new-global-guidelines-for-pregnant-women-with-ibd-are-here","status":"publish","type":"post","link":"https:\/\/portfolio.zenkoders.com\/ai-powered\/new-global-guidelines-for-pregnant-women-with-ibd-are-here\/","title":{"rendered":"New Global Guidelines for Pregnant Women With IBD Are Here"},"content":{"rendered":"<header class=\"PageHeader_description__GYAA6\">\n<p class=\"Markdown_md__UVFG1 PageHeader_description__GYAA6 display-standard\">Clear advice on how best to manage pregnancy and Crohn\u2019s disease or ulcerative colitis aims to clear up confusion on which meds are safe for expectant moms.<\/p>\n<\/header>\n<section>\n<div class=\"PageHeader_contributorSection__9odbd body-small\">\n<div class=\"PageHeader_bylines__BS2pr\">\n<div class=\"PageHeader_authorSection__RpGws\">\n<p class=\"rt-p\">For women with\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.healthcentral.com\/condition\/inflammatory-bowel-disease\/what-is-inflammatory-bowel-disease-ibd\" target=\"_self\" rel=\"\">inflammatory bowel disease<\/a>\u00a0(IBD), including\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.healthcentral.com\/community\/crohns-disease\" target=\"_self\" rel=\"\">Crohn\u2019s disease<\/a>\u00a0and\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.healthcentral.com\/community\/ulcerative-colitis\" target=\"_self\" rel=\"\">ulcerative colitis<\/a>\u00a0(UC), confusion over potential pregnancy complications is common, says\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.sjpp.org\/find-a-doctor\/sheryl-ross-md\/\" target=\"_blank\" rel=\"noopener\">Sherry Ross, M.D.<\/a>, a women\u2019s health expert and OB\/GYN at Providence Saint John\u2019s Health Center in Santa Monica, CA.<\/p>\n<p class=\"rt-p\">\u201cThere has been quite a bit of misinformation and fear around this topic, with some women becoming anxious that they\u2019ll flare during pregnancy or that taking certain medications might be dangerous,\u201d she says. \u201cIt\u2019s crucial to understand that women with IBD can have healthy, safe pregnancies with regular monitoring and support from a care team.\u201d<\/p>\n<p class=\"rt-p\">Now, expectant IBD moms and their health providers have better guidance than ever. That\u2019s because this past summer an international consortium of Crohn\u2019s and UC specialists, as well as patient advocates, issued 34 recommendations and 35 consensus statements for IBD specialists to follow to help resolve inconsistencies in previous pregnancy guidance\u2014all as part of the\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.cghjournal.org\/article\/S1542-3565%2825%2900322-2\/fulltext\" target=\"_blank\" rel=\"noopener\">first unified global guidelines for managing pregnancy in women with IBD<\/a>.<\/p>\n<div class=\"SectionBreaker_sectionBreaker__mjMHL\">\n<div class=\"SectionBreaker_breaker__T1iK5\">\n<div class=\"SectionBreaker_breakerTitle__KpxMd body-standard-heavy\">Addressing Complications<\/div>\n<div class=\"SectionBreaker_breakerLine__jpsqa\"><\/div>\n<\/div>\n<h2 id=\"addressing-complications\" class=\"SectionBreaker_titleWithBreaker__YUQRt\">Addressing Complications in IBD Pregnancies<\/h2>\n<\/div>\n<p class=\"rt-p\">Pregnant women with IBD face many challenges, says\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/keciagaither.com\/\" target=\"_blank\" rel=\"noopener\">Kecia Gaither, M.D.<\/a>, an OB\/GYN and director of perinatal services and maternal fetal medicine at NYC Health + Hospitals\/Lincoln in New York City. Risks include pre-term delivery and low birth weight, she notes, since the chances of such outcomes occurring are higher for those with active disease and symptoms.<\/p>\n<p class=\"rt-p\">That\u2019s not all, though. Research published in the\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/35612619\/\" target=\"_blank\" rel=\"noopener\"><i>International Journal of Colorectal Diseases<\/i><\/a>\u00a0looked at the outcomes of pregnancies among women with IBD and found higher incidence of gestational\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.healthcentral.com\/condition\/diabetes\" data-xlink=\"true\">diabetes<\/a>, postpartum hemorrhage, and hypertensive complications, along with pre-term delivery and low birth weight babies, compared to pregnancies in women without IBD. The studied cohort also tended to have longer hospital stays after delivery. Additional research in\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC8040511\/\" target=\"_blank\" rel=\"noopener\"><i>Frontline Gastroenterology<\/i><\/a>\u00a0emphasized that while roughly 80% of pregnancies in expectant mothers with IBD were uncomplicated, it was important for both physicians and pregnant patients to be aware of potential health complications, says Dr. Gaither.<\/p>\n<p class=\"rt-p\">\u201cDisease remission prior to conception and continued effective disease management during pregnancy are crucial to minimizing risks to both mother and fetus,\u201d she explains. \u201cCollaboration among gastroenterologists, maternal fetal medicine specialists, obstetricians and other specialists is advised for optimal care.\u201d Although Dr. Gaither wasn\u2019t involved in the development of the recent guidelines, she believes they\u2019re an important step forward.<\/p>\n<div class=\"styles_waypointMarker__j_1yz\"><\/div>\n<div class=\"SectionBreaker_sectionBreaker__mjMHL\">\n<div class=\"SectionBreaker_breaker__T1iK5\">\n<div class=\"SectionBreaker_breakerTitle__KpxMd body-standard-heavy\">Real-World Context<\/div>\n<\/div>\n<h2 id=\"real-world-context\" class=\"SectionBreaker_titleWithBreaker__YUQRt\">Putting Guidelines in Real-World Context<\/h2>\n<\/div>\n<p class=\"rt-p\">The new guidance is designed to replace the kind of conflicting advice that has long led to uncertainty among both IBD specialists and their pregnant patients, Dr. Gaither notes. Key pieces of advice in the guidelines for physicians\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.cghjournal.org\/cms\/10.1016\/j.cgh.2025.04.005\/asset\/2a92e02f-4da0-414d-a913-13b847c7440f\/main.assets\/ga1_lrg.jpg\" target=\"_blank\" rel=\"noopener\">include recommendations<\/a>\u00a0to:<\/p>\n<div>\n<div class=\"SectionBreaker_sectionBreaker__mjMHL\">\n<h2 id=\"real-world-context\" class=\"SectionBreaker_titleWithBreaker__YUQRt\">Putting Guidelines in Real-World Context<\/h2>\n<\/div>\n<p class=\"rt-p\">The new guidance is designed to replace the kind of conflicting advice that has long led to uncertainty among both IBD specialists and their pregnant patients, Dr. Gaither notes. Key pieces of advice in the guidelines for physicians\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.cghjournal.org\/cms\/10.1016\/j.cgh.2025.04.005\/asset\/2a92e02f-4da0-414d-a913-13b847c7440f\/main.assets\/ga1_lrg.jpg\" target=\"_blank\" rel=\"noopener\">include recommendations<\/a>\u00a0to:<\/p>\n<aside class=\"promosWrapper\">\n<section class=\"PromoInline_infoSection__aQ1qc\"><\/section>\n<\/aside>\n<h3 class=\"rt-h3\">Assess Nutritional Status for Deficiencies<b><\/b><\/h3>\n<p class=\"rt-p\">Women with IBD are already at risk of developing malnutrition and micronutrient shortfalls due to factors like restrictive diets, frequent diarrhea, and malabsorption of vitamins and minerals, the guideline authors note. \u201cPregnancy may further worsen these deficits because of increased micronutrient, protein, and energy requirements essential for normal fetal development,\u201d they write. Because of that, it\u2019s essential for providers to evaluate and identify any nutritional challenges and treat them with supplements if needed.<\/p>\n<h3 class=\"rt-h3\">Avoid Small-Molecule Drugs During Pregnancy and Lactation<\/h3>\n<p class=\"rt-p\">These are\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.cancer.gov\/publications\/dictionaries\/cancer-terms\/def\/small-molecule-drug\" target=\"_blank\" rel=\"noopener\">medications that can enter cells easily<\/a>\u00a0(unlike large-molecule drugs such as biologics). Examples include ibuprofen, acetaminophen, statins, and some antihistamines. For IBD specifically,\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/journals.lww.com\/cmj\/fulltext\/2024\/03050\/new_progress_of_small_molecule_drugs_in_the.6.aspx\" target=\"_blank\" rel=\"noopener\">small-molecule drugs<\/a>\u00a0include JAK inhibitors such as\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.healthcentral.com\/drugs\/monograph\/177760-2082\/rinvoq\" data-xlink=\"true\">Rinvoq<\/a>\u00a0(upadacitinib) and\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.healthcentral.com\/drugs\/monograph\/162865-1509\/xeljanz\" data-xlink=\"true\">Xeljanz<\/a>\u00a0(tofacitinib) and S1P receptor modulators such as Zeposia (<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.healthcentral.com\/drugs\/monograph\/179398-2226\/zeposia\" data-xlink=\"true\">ozanimod<\/a>). According to the\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0168365923004534\" target=\"_blank\" rel=\"noopener\"><i>Journal of Controlled Release<\/i><\/a>, small-molecule drugs can cross the placenta, which raises risk to a fetus\u2019 development.<\/p>\n<h3 class=\"rt-h3\">Continue With Biologics and Thiopurines<\/h3>\n<p class=\"rt-p\">The use of biologics throughout pregnancy and lactation has been one of the biggest sources of confusion and\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.healthcentral.com\/condition\/anxiety\" data-xlink=\"true\">anxiety<\/a>\u00a0for those who are pregnant and have IBD, leading some to believe that use of any medication for IBD will harm a fetus, says Dr. Ross. Having this clear guidance should provide some assurance for expectant IBD mothers who might be concerned that they have to change their treatment plan due to pregnancy, she adds. In the consensus statement, the experts write that \u201cmedication cessation leads to an increase in disease activity, which then is associated with an increase in maternal and fetal adverse outcomes.\u201d<\/p>\n<h3 class=\"rt-h3\">Reduce Preterm Preeclampsia Risk With Low-Dose Aspirin<\/h3>\n<p class=\"rt-p\">Due to systemic\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.healthcentral.com\/pain-management\/inflammation\" data-xlink=\"true\">inflammation<\/a>\u00a0and the immune system dysregulation that can cause, pregnant women with IBD are more likely to develop preeclampsia. That happens because immune dysfunction can affect the placenta, a key factor in preeclampsia. Low-dose aspirin can lower inflammation and improve blood flow to the placenta.<\/p>\n<p class=\"rt-p\">That&#8217;s why recommending low-dose aspirin\u00a0<a class=\"RichText_link__D1r_T\" href=\"https:\/\/www.acog.org\/clinical\/clinical-guidance\/practice-advisory\/articles\/2021\/12\/low-dose-aspirin-use-for-the-prevention-of-preeclampsia-and-related-morbidity-and-mortality\" target=\"_blank\" rel=\"noopener\">has been a longstanding practice<\/a>\u00a0for those with higher preeclampsia risk, according to Dr. Ross, but it\u2019s helpful to have it clarified in the guidelines. Technically, aspirin is a small-molecule drug, but it is safer when given in low doses, the guidelines suggest. Also, the guideline authors add that women with IBD may be at higher risk of developing preterm preeclampsia.<\/p>\n<div class=\"SectionBreaker_sectionBreaker__mjMHL\">\n<div class=\"SectionBreaker_breaker__T1iK5\">\n<div class=\"SectionBreaker_breakerTitle__KpxMd body-standard-heavy\">High-Risk Pregnancies<\/div>\n<div class=\"SectionBreaker_breakerLine__jpsqa\"><\/div>\n<\/div>\n<h2 id=\"high-risk-pregnancies\" class=\"SectionBreaker_titleWithBreaker__YUQRt\">With IBD, All Pregnancies Are High-Risk<\/h2>\n<\/div>\n<p class=\"rt-p\">The new global guidelines propose that even those in remission who are likely to have uncomplicated pregnancies should be considered high-risk. Viewing them as such will lead to more frequent monitoring, suggests Dr. Gaither.<\/p>\n<p class=\"rt-p\">That\u2019s important, conclude the 39 physicians and seven patient advocates who worked on these guidelines, because women with IBD often don\u2019t receive appropriate counseling and education surrounding pregnancy-related concerns. The hope is that these guidelines will help to change that situation.<\/p>\n<p class=\"rt-p\">\u201cThe guidelines are quite comprehensive,\u201d Dr. Gaither points out. \u201cThey give cogent advice as to necessary care that needs to be rendered to the pregnant patient with IBD.\u201d<\/p>\n<\/div>\n<\/div>\n<\/div>\n<\/div>\n<\/section>\n","protected":false},"excerpt":{"rendered":"<p>Clear advice on how best to manage pregnancy and Crohn\u2019s disease or ulcerative colitis aims to clear up confusion on which meds are safe for expectant moms. For women with\u00a0inflammatory bowel disease\u00a0(IBD), including\u00a0Crohn\u2019s disease\u00a0and\u00a0ulcerative colitis\u00a0(UC), confusion over potential pregnancy complications is common, says\u00a0Sherry Ross, M.D., a women\u2019s health expert and OB\/GYN at Providence Saint John\u2019s [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":845,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[9],"tags":[],"class_list":["post-775","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-articles"],"acf":[],"_links":{"self":[{"href":"https:\/\/portfolio.zenkoders.com\/ai-powered\/wp-json\/wp\/v2\/posts\/775","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/portfolio.zenkoders.com\/ai-powered\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/portfolio.zenkoders.com\/ai-powered\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/portfolio.zenkoders.com\/ai-powered\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/portfolio.zenkoders.com\/ai-powered\/wp-json\/wp\/v2\/comments?post=775"}],"version-history":[{"count":1,"href":"https:\/\/portfolio.zenkoders.com\/ai-powered\/wp-json\/wp\/v2\/posts\/775\/revisions"}],"predecessor-version":[{"id":776,"href":"https:\/\/portfolio.zenkoders.com\/ai-powered\/wp-json\/wp\/v2\/posts\/775\/revisions\/776"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/portfolio.zenkoders.com\/ai-powered\/wp-json\/wp\/v2\/media\/845"}],"wp:attachment":[{"href":"https:\/\/portfolio.zenkoders.com\/ai-powered\/wp-json\/wp\/v2\/media?parent=775"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/portfolio.zenkoders.com\/ai-powered\/wp-json\/wp\/v2\/categories?post=775"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/portfolio.zenkoders.com\/ai-powered\/wp-json\/wp\/v2\/tags?post=775"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}