Persistent period pain is just not talked about enough. If you are having persistent period pain that keeps you from going to school, work or just getting out of bed, you should make an appointment to see your health care provider. Period pain that is unresponsive to over the counter treatment options including NSAID or Tylenol or other lifestyle changes you should speak to your health care provider. Persistent irregular and heavy bleeding, pelvic pain and pressure, anemia, constipation, difficulty with urination, abdominal pain, miscarriages, dizziness, weakness, feeling cold, fatigue or trouble breathing are all signs and symptoms that you should follow up with your health care provider.