Some women with endometriosis may experience pain with sex depending on where the endometrial implants are located in the pelvis. If the implants are on nerves, ligaments and tissue stretched during sex, pain can be significant and, often, unbearable lasting hours and days afterwards making sex impossible. The pain during sex can be so horrible that many women will not be able to have sexual penetration. This can have permanent mental and physical consequences on a sexual relationship.